The HD/PulseWave™ CR-2000: An easy-to-use, non-invasive System designed for research purposes.

The HD/PulseWave™ CR-2000 is a complete system that requires no additional accessories.

The HD/PulseWave™ CR-2000 Research CardioVascular Profiling System provides researchers and scientists with a non-invasive means to assess arterial elasticity in support of human research in a variety of areas including:

• Pharmaceutical Studies

• Hypertension

• Diabetes

• Smoking

• Hormone Replacement Therapy (HRT)

• Hyperlipidemia

• Diet and Exercise

• Renal Failure

• Endothelial Function

• Aging

• Women's Health

By analyzing non-invasively derived blood pressure waveform data obtained through HD’s proprietary Arterial PulseWave™ Sensor, the CR-2000 provides information that correlates with 15 cardiovascular parameters:

• Blood Pressure Waveform

• Systolic Blood Pressure

• Diastolic Blood Pressure

• Mean Arterial Blood Pressure

• Pulse Pressure

• Pulse Rate

• Estimated Cardiac Ejection Time

• Estimated Stroke Volume

• Estimated Stroke Volume Index

• Estimated Cardiac Output

• Estimated Cardiac Index

• Large Artery Elasticity Index (Capacitive Arterial Compliance)

• Small Artery Elasticity Index (Oscillatory/Reflective Arterial Compliance)

• Systemic Vascular Resistance

• Total Vascular Impedance

NOTE: In the United States, the HD/PulseWave™ CR-2000 Research CardioVascular Profiling System is for research purposes only.

The HD/PulseWave™ Research System has a medical device CE Mark which allows it to be marketed in the European Union. The CR-2000 Research System is available in the following languages: English, German, Italian and Spanish.